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Nitro-Time and Vasopressin Injection

Determining the interaction of Nitro-Time and Vasopressin Injection and the possibility of their joint administration.

Check result:

Nitro-Time <> Vasopressin Injection

Relevance: 16.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Nitroglycerin has been used safely and successfully to counteract some of the potentially deleterious pressor effects of vasopressin. The combination may be particularly useful if vasopressin is required in a patient with known or suspected coronary artery disease. Animal data have shown that neither drug significantly affects the plasma clearance of the other. While nitroglycerin and vasopressin have opposing hemodynamic effects, the interaction has been used to clinical advantage.

References

Sirinek KR, Adcock DK, Levine BA "Simultaneous infusion of nitroglycerin and nitroprusside to offset adverse effects of vasopressin during portosystemic shunting." Am J Surg 157 (1989): 33-7
Blei AT, Friedman S, Gottstein J, Robertson G, Fung HL "Pharmacokinetic-hemodynamic interactions between vasopressin and nitroglycerin: comparison between intravenous and cutaneous routes of nitrate delivery." Hepatology 5 (1985): 264-70

Nitro-Time

Generic Name: nitroglycerin

Brand name: Nitro-Time, Gonitro, Nitrolingual, NitroMist, Nitrostat, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: n.a.

What is Nitro-Time?

Vasopressin Injection

Generic Name: vasopressin

Brand name: Vasostrict, Pitressin, Pitressin Synthetic

Synonyms: Vasopressin

What is Vasopressin Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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