Nitrofurantoin Capsules and Triactin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Anticholinergic agents may increase the absorption and oral bioavailability of nitrofurantoin. The proposed mechanism involves increased gastrointestinal transit time due to reduction of stomach and intestinal motility by anticholinergic agents. In six healthy volunteers, pretreatment with propantheline 45 minutes before a single 100 mg dose of nitrofurantoin significantly increased the oral bioavailability of nitrofurantoin as indicated by a 68% increase in urinary recovery. In another study, atropine 500 mcg given subcutaneously one-half hour before a single 100 mg dose of nitrofurantoin delayed the absorption and urinary excretion of nitrofurantoin but did not affect its overall bioavailability in ten healthy volunteers. The clinical significance of these changes is unknown.

Nitrofurantoin Capsules

Generic Name: nitrofurantoin

Brand name: Furadantin, Macrobid, Macrodantin, Nitro Macro

Synonyms: Nitrofurantoin

What is Nitrofurantoin Capsules?

Triactin

Generic Name: dicyclomine

Brand name: Bentyl, Dibent, Dicyclocot

Synonyms: Dicyclomine

What is Triactin?