Nitrofurantoin Oral Suspension and Phenytoin Sodium
Determining the interaction of Nitrofurantoin Oral Suspension and Phenytoin Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking nitrofurantoin, tell your doctor if you also use phenytoin. You may need dose adjustments or special tests in order to safely take both medications together. You should notify your doctor if you have loss of seizure control. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: One patient experienced seizures and a drop in phenytoin levels while taking concurrent nitrofurantoin. Phenytoin levels rose when nitrofurantoin was discontinued. The mechanism is unknown but may be related to induction of hepatic metabolism by nitrofurantoin. A similar reaction may occur with other hydantoins.
MANAGEMENT: Phenytoin serum concentrations should be monitored during coadministration of these agents. Patients should be advised to promptly report loss of seizure control to their caregiver.
- Heipertz R, Pilz H "Interaction of nitrofurantoin with diphenylhydantoin." J Neurol 218 (1978): 297-301
Generic Name: nitrofurantoin
Brand name: Furadantin, Macrobid, Macrodantin, Nitro Macro
Synonyms: Nitrofurantoin
Generic Name: phenytoin
Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nitrofurantoin Oral Suspension-Phenytoin Sodium, Prompt injection
- Nitrofurantoin Oral Suspension-Phenytoin Suspension
- Nitrofurantoin Oral Suspension-Philith
- Nitrofurantoin Oral Suspension-Phillips Milk of Magnesia
- Nitrofurantoin Oral Suspension-Phisohex
- Nitrofurantoin Oral Suspension-Phl-Fluoxetine
- Phenytoin Sodium-Nitroglycerin
- Phenytoin Sodium-Nitroglycerin Controlled-Release Capsules
- Phenytoin Sodium-Nitroglycerin Dextrose
- Phenytoin Sodium-Nitroglycerin ER
- Phenytoin Sodium-Nitroglycerin in Dextrose
- Phenytoin Sodium-Nitroglycerin Injection