Nitroglycerin and Rosiglitazone and glimepiride
Determining the interaction of Nitroglycerin and Rosiglitazone and glimepiride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using rosiglitazone together with nitroglycerin. Combining these medications may increase the risk of chest pain and heart problems. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek immediate medical attention if you experience symptoms of chest pain or tightness in your chest. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: The concomitant use of rosiglitazone with nitrates may increase the risk of myocardial ischemia. Results of clinical trials have suggested that rosiglitazone is associated with a higher risk of angina or myocardial infarction. In patients also taking nitrates, the risk was increased by 12 events per 100 patient years. However, long term trials have not been conducted.
MANAGEMENT: The concomitant use of rosiglitazone and nitrates should generally be avoided.
- "Product Information. Avandia (rosiglitazone)" SmithKline Beecham, Philadelphia, PA.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Generic Name: nitroglycerin
Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv
Synonyms: Nitroglycerin (oral/sublingual)
Generic Name: glimepiride / rosiglitazone
Brand name: Avandaryl
Synonyms: Rosiglitazone and glimepiride (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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