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Nitrolingual and Pancuronium

Determining the interaction of Nitrolingual and Pancuronium and the possibility of their joint administration.

Check result:
Nitrolingual <> Pancuronium
Relevance: 08.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using pancuronium together with nitroglycerin may increase the effects of pancuronium. You should be closely monitored for prolong breathing cessation. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Animal studies have suggested that intravenous nitroglycerin may enhance the effect of pancuronium by an unknown mechanism.

MANAGEMENT: Patients should be closely monitored for excessive or prolonged neuromuscular blockade. Weaning from ventilators may be prolonged.

References
  • Glisson SN, El-Etr AA, Lim R "Prolongation of pancuronium-induced neuromuscular blockade by intravenous infusion of nitroglycerin." Anesthesiology 51 (1979): 47-9
Nitrolingual

Generic Name: nitroglycerin

Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: n.a.

Pancuronium

Generic Name: pancuronium

Brand name:

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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