Nitrolingual and Sildenafil Tablets (Erectile Dysfunction)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using sildenafil together with nitroglycerin is not recommended. Combining these medications may cause blood pressure to fall excessively, which can lead to cardiovascular collapse. The risk of other side effects such as dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity) may also increase. You should seek immediate medical attention if you experience chest pain or tightness during treatment with sildenafil. Do not use nitroglycerin on your own without consulting your doctor, even if it has been a few days since you have taken a dose of sildenafil. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Phosphodiesterase-5 (PDE5) inhibitors may potentiate the hypotensive effect of organic nitrates. Severe hypotension, syncope, or myocardial ischemia may result from use of the combination. The mechanism involves peripheral vasodilation secondary to enhanced levels of cyclic guanosine monophosphate (cGMP) in vascular smooth muscle cells, as PDE5 inhibitors prevent degradation of cGMP while nitrates promote its synthesis. Single oral doses of the PDE5 inhibitors sildenafil (100 mg) and vardenafil (20 mg) have produced mean maximum decreases in supine blood pressure (systolic/diastolic) of approximately 8.4/5.5 and 7.0/8.0 mmHg, respectively, compared to placebo. The decrease in blood pressure was most notable approximately 1 to 2 hours after sildenafil dosing and 1 to 4 hours after vardenafil dosing and was additive with that produced by nitrates. A single 200 mg dose of avanafil produced transient decreases in sitting blood pressure of 8.0/3.3 mmHg in healthy volunteers, with maximum decrease observed at 1 hour after dosing. When given with sublingual nitroglycerin 0.4 mg to healthy males, avanafil 200 mg produced decreases from baseline in sitting and standing blood pressure of 8.2/6.4 and 6.9/7.0 mmHg, respectively, relative to placebo. Tadalafil 20 mg administered to healthy male subjects produced no significant difference in supine or standing blood pressure compared to placebo, although the drug did potentiate the hypotensive effect of nitrates at a dosage of 5 to 20 mg.

MANAGEMENT: The use of PDE5 inhibitors in patients receiving organic nitrates or other nitric oxide donors, either regularly or intermittently, is considered contraindicated. A suitable time interval following sildenafil or vardenafil use for the safe administration of nitrates has not been determined. For patients treated with avanafil or tadalafil, at least 12 hours after the last dose of avanafil and 48 hours after the last dose of tadalafil are recommended before nitrate administration, should it be deemed medically necessary in a life-threatening situation. Even then, nitrates should only be administered under close medical supervision with appropriate hemodynamic monitoring. Patients should be advised to seek immediate medical attention if they experience anginal chest pain after taking a PDE5 inhibitor.

Nitrolingual

Generic Name: nitroglycerin

Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: n.a.

What is Nitrolingual?

Sildenafil Tablets (Erectile Dysfunction)

Generic Name: sildenafil

Brand name: Revatio, Viagra

Synonyms: Sildenafil

What is Sildenafil Tablets (Erectile Dysfunction)?