Nizoral and Phenytoin Intravenous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ketoconazole together with phenytoin may alter the blood levels and effects of both drugs. Using these medications together may cause ketoconazole to be less effective. Contact your doctor immediately if your fungal infection worsens or if you experience twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Phenytoin and other hydantoins may reduce itraconazole serum levels by up to 90%. The mechanism appears to be enhanced first-pass metabolism and hepatic enzyme metabolism (CYP450 3A4) of itraconazole. Itraconazole therapy may fail. Ketoconazole is affected in a similar manner. In addition, itraconazole may increase the plasma concentrations of phenytoin.

MANAGEMENT: Authorities recommend avoiding concurrent use of itraconazole with, and within two weeks of discontinuation of phenytoin. Some experts suggest that if concomitant use is unavoidable, a dosage increase for itraconazole or ketoconazole should be considered. In addition, monitoring of phenytoin concentrations is recommended and the dosage adjusted if needed. Fluconazole is eliminated unchanged by the kidneys and may be a more appropriate antifungal agent, depending on the patient's condition.

Nizoral

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: n.a.

What is Nizoral?

Phenytoin Intravenous

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin (Intravenous)

What is Phenytoin Intravenous?