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Nizoral and Pms-Isoniazid

Determining the interaction of Nizoral and Pms-Isoniazid and the possibility of their joint administration.

Check result:

Nizoral <> Pms-Isoniazid

Relevance: 07.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using isoniazid together with ketoconazole. Using these medications together may decrease the effects of ketoconazole. Contact your doctor if your condition or infection worsens. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The concomitant administration of potent CYP450 3A4 inducers may significantly reduce itraconazole and ketoconazole serum levels. The mechanism appears to be enhanced first-pass metabolism and hepatic enzyme metabolism (CYP450 3A4) of the antifungal agents. Antifungal therapy may fail.

MANAGEMENT: This combination should be avoided. Fluconazole is eliminated unchanged by the kidneys and may be a more appropriate antifungal agent, depending on the patient's condition.

References

"Product Information. Nizoral (ketoconazole)." Janssen Pharmaceutica, Titusville, NJ.

Nizoral

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: n.a.

What is Nizoral?

Pms-Isoniazid

Generic Name: isoniazid

Brand name: Nydrazid

Synonyms: Isoniazid

What is Pms-Isoniazid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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