Nizoral and Probenecid and colchicine
Determining the interaction of Nizoral and Probenecid and colchicine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using colchicine together with ketoconazole is not recommended. Combining these medications may increase the blood levels of colchicine to dangerous levels, increasing the risk of serious side effects that can affect your muscles, blood cells, nervous system, and multiple organs including the liver and kidneys. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Coadministration with potent inhibitors of CYP450 3A4 such as ketoconazole may significantly increase the serum concentrations of colchicine, which is primarily metabolized by the isoenzyme. Clinical toxicity including myopathy, neuropathy, multiorgan failure, and pancytopenia may occur.
MANAGEMENT: Due to the risk of life-threatening and fatal toxicity, concomitant use of colchicine with ketoconazole is considered contraindicated.
- "Product Information. Colcrys (colchicine)." AR Scientific Inc, Philadelphia, PA.
- "Colchicine: serious interactions." Prescrire Int 17 (2008): 151-3
- "Product Information. Nizoral (ketoconazole)." Janssen Pharmaceutica, Titusville, NJ. (1992):
Generic Name: colchicine / probenecid
Brand name:
Synonyms: Probenecid and colchicine (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Nizoral-Probenecid Tablets
- Nizoral-Probiotic Formula (Bacillus Coagulans)
- Nizoral-Probucol
- Nizoral-Probuphine
- Nizoral-Procainamide
- Nizoral-Procainamide capsules
- Probenecid and colchicine-No Doz Maximum Strength
- Probenecid and colchicine-Nocdurna
- Probenecid and colchicine-Noctiva
- Probenecid and colchicine-Noctiva nasal
- Probenecid and colchicine-Nodolor
- Probenecid and colchicine-Nodolor Capsules