Norepinephrine and Sinemet 25-100
Determining the interaction of Norepinephrine and Sinemet 25-100 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Both levodopa and norepinephrine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with levodopa may potentiate the cardiovascular effects of sympathomimetic agents (e.g., epinephrine, norepinephrine, isoproterenol, amphetamine). Additive increases in blood pressure and heart rate may occur due to enhanced sympathetic activity. However, data evaluating the interaction are not available.
MANAGEMENT: The use of levodopa with sympathomimetic agents should generally be avoided. If concomitant use is required, close monitoring of the cardiovascular system is recommended and the dose of the sympathomimetic agent may need to be reduced.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: norepinephrine
Brand name: Levophed, Levophed Bitartrate
Synonyms: n.a.
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: Carbidopa and levodopa, Carbidopa and Levodopa
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Norepinephrine-Sinemet 25-250
- Norepinephrine-Sinemet 250/25
- Norepinephrine-Sinemet CR
- Norepinephrine-Sinemet CR 100/25
- Norepinephrine-Sinemet CR 200/50
- Norepinephrine-Sinequan
- Sinemet 25-100-Norepinephrine Bitartrate
- Sinemet 25-100-Norepinephrine Injection Concentrate
- Sinemet 25-100-Norethindrone
- Sinemet 25-100-Norethindrone (Contraceptive)
- Sinemet 25-100-Norethindrone (Hormone Replacement Therapy)
- Sinemet 25-100-Norethindrone Acetate