Northera and Stalevo 50
Determining the interaction of Northera and Stalevo 50 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Carbidopa may reduce the effects of droxidopa. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with dopa-decarboxylase inhibitors such as carbidopa may reduce the therapeutic efficacy of droxidopa, which is directly metabolized in vivo to norepinephrine via decarboxylation. Droxidopa is believed to exert its pharmacological effects through norepinephrine and not through the parent molecule or other metabolites.
MANAGEMENT: Dosage adjustments for droxidopa may be required during coadministration with dopa-decarboxylase inhibitors if an interaction is suspected.
- "Product Information. Northera (droxidopa)." Chelsea Therapeutics Inc, Charlotte, NC.
Generic Name: carbidopa / entacapone / levodopa
Brand name: Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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