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Novo-Cholamine and Ocaliva

Determining the interaction of Novo-Cholamine and Ocaliva and the possibility of their joint administration.

Check result:

Novo-Cholamine <> Ocaliva

Relevance: 04.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Cholestyramine may interfere with the absorption of obeticholic acid and reduce its levels in the bloodstream. This may make the medication less effective in treating your condition. You should take obeticholic acid at least 4 hours before or 4 hours after cholestyramine, or separate the dosing times by as much as possible if a 4 hour interval is not achievable. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Because bile acid sequestrants adsorb and reduce bile acid absorption, they may reduce the bioavailability and efficacy of obeticholic acid during concomitant administration.

MANAGEMENT: When used with a bile acid sequestrant, obeticholic acid should be administered at least 4 hours before or 4 hours after dosing of the bile acid sequestrant, or at as great an interval as possible.

References

"Product Information. Ocaliva (obeticholic acid)." Intercept Pharmaceuticals, Inc., New York, NY.

Novo-Cholamine

Generic Name: cholestyramine

Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets

Synonyms: Cholestyramine, Cholestyramine Resin

What is Novo-Cholamine?

Ocaliva

Generic Name: obeticholic acid

Brand name: Ocaliva

Synonyms: n.a.

What is Ocaliva?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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