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Novo-Methacin Suppositories and Zidovudine Capsules and Tablets

Determining the interaction of Novo-Methacin Suppositories and Zidovudine Capsules and Tablets and the possibility of their joint administration.

Check result:

Novo-Methacin Suppositories <> Zidovudine Capsules and Tablets

Relevance: 27.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using zidovudine together with indomethacin may increase the risk of bleeding in HIV-positive patients with hemophilia. However, the interaction is not fully understood, and evidence is limited. Talk to your doctor or pharmacist if you have any concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited clinical data suggest that the concomitant use of zidovudine with nonsteroidal anti-inflammatory agents may increase the risk of hematological toxicity and/or bleeding in HIV-positive patients with hemophilia. The mechanism is unknown.

MANAGEMENT: It is recommended to monitor patients for side effects and bleeding during concomitant use.

References

Barry M, Howe J, Back D, et al "The effects of indomethacin and naproxen on zidovudine pharmacokinetics." Br J Clin Pharmacol 36 (1993): 82-5
Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0

Novo-Methacin Suppositories

Generic Name: indomethacin

Brand name: Indocin, Indocin SR, Tivorbex

Synonyms: Indomethacin

What is Novo-Methacin Suppositories?

Zidovudine Capsules and Tablets

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Zidovudine (oral/injection), Zidovudine

What is Zidovudine Capsules and Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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