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Novolin 70/30 (Insulin NPH and Insulin Regular (Vials)) and Tolazamide

Determining the interaction of Novolin 70/30 (Insulin NPH and Insulin Regular (Vials)) and Tolazamide and the possibility of their joint administration.

Check result:
Novolin 70/30 (Insulin NPH and Insulin Regular (Vials)) <> Tolazamide
Relevance: 25.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.ADJUST DOSE: Coadministration of a sulfonylurea with insulin may potentiate the risk of hypoglycemia. Elderly, debilitated, or malnourished patients, and those with adrenal or pituitary insufficiency, are particularly susceptible to the hypoglycemic action of glucose-lowering drugs. MANAGEMENT: Caution and close blood glucose monitoring are advised during coadministration of these agents. A lower dosage of sulfonylurea or insulin may be required. Patients should be counseled to recognize the symptoms of hypoglycemia such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitation, and tachycardia. If hypoglycemia occurs, patients should initiate appropriate remedial therapy immediately and contact their physician. Patients should also be advised to take precautions to avoid hypoglycemia while driving or operating hazardous machinery. References "Product Information. Glucotrol (glipizide)." Pfizer US Pharmaceuticals, New York, NY. "Product Information. Humulin R (insulin regular)." Lilly, Eli and Company, Indianapolis, IN. Cerner Multum, Inc. "Australian Product Information." O 0 "Product Information. Humulin N (insulin isophane)." Lilly, Eli and Company, Indianapolis, IN. "Product Information. Afrezza (insulin inhalation, rapid acting)." MannKind Corporation, Valencia, CA. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Diabeta (glyburide)." Hoechst Marion-Roussel Inc, Kansas City, MO. "Product Information. Amaryl (glimepiride)." Hoechst Marion-Roussel Inc, Kansas City, MO. "Product Information. NovoLIN R (insulin regular)." Novo Nordisk Pharmaceuticals Inc, Princeton, NJ. American Diabetes Association "9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2019" Diabetes Care 42 (2019): S90-S102 View all 10 references

Professional:

ADJUST DOSE: Coadministration of a sulfonylurea with insulin may potentiate the risk of hypoglycemia. Elderly, debilitated, or malnourished patients, and those with adrenal or pituitary insufficiency, are particularly susceptible to the hypoglycemic action of glucose-lowering drugs.

MANAGEMENT: Caution and close blood glucose monitoring are advised during coadministration of these agents. A lower dosage of sulfonylurea or insulin may be required. Patients should be counseled to recognize the symptoms of hypoglycemia such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitation, and tachycardia. If hypoglycemia occurs, patients should initiate appropriate remedial therapy immediately and contact their physician. Patients should also be advised to take precautions to avoid hypoglycemia while driving or operating hazardous machinery.

References
  • "Product Information. Glucotrol (glipizide)." Pfizer US Pharmaceuticals, New York, NY.
  • "Product Information. Humulin R (insulin regular)." Lilly, Eli and Company, Indianapolis, IN.
  • Cerner Multum, Inc. "Australian Product Information." O 0
  • "Product Information. Humulin N (insulin isophane)." Lilly, Eli and Company, Indianapolis, IN.
  • "Product Information. Afrezza (insulin inhalation, rapid acting)." MannKind Corporation, Valencia, CA.
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  • "Product Information. Diabeta (glyburide)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  • "Product Information. Amaryl (glimepiride)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  • "Product Information. NovoLIN R (insulin regular)." Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
  • American Diabetes Association "9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2019" Diabetes Care 42 (2019): S90-S102
Novolin 70/30 (Insulin NPH and Insulin Regular (Vials))

Generic Name: insulin isophane / insulin regular

Brand name: Humulin 70/30, HumuLIN 70/30 KwikPen, Novolin 70/30, ReliOn/Novolin 70/30, Humulin 50/50, Insulin Pork Mix, HumuLIN 70/30 Pen, NovoLIN 70/30 Innolet, NovoLIN 70/30 PenFill, Relion NovoLIN 70/30 Innolet, NovoLIN 70/30 FlexPen, ReliOn/NovLIN 70/30 FlexPen, Humulin 50/50, Novolin 70/30

Synonyms: Insulin isophane and insulin regular, Insulin NPH and Insulin Regular

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.