Novothyrox and Rifampin Injection
Determining the interaction of Novothyrox and Rifampin Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using rifAMPin together with levothyroxine may decrease the effects of levothyroxine. Contact your doctor if you experience tiredness sluggishness, weakness, memory problems, depression, difficulty concentrating, and constipation. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Rifampin may decrease exogenous levothyroxine plasma concentrations resulting in elevated thyroid stimulating hormone (TSH) and exacerbation of hypothyroidism. The mechanism may be induction of hepatic CYP450 enzymes responsible for levothyroxine metabolism. Liothyronine may be similarly affected.
MANAGEMENT: Clinical monitoring of patient response, including laboratory serum TSH concentrations, is recommended. Adjustment of thyroid hormone dosage may be indicated when initiating or discontinuing rifampin therapy.
- "Product Information. Rifadin (rifampin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
- Nolan SR, Self TH, Norwood JM "Interaction between rifampin and levothyroxine." South Med J 92 (1999): 529-31
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: levothyroxine
Brand name: Euthyrox, Levoxyl, Synthroid, Tirosint, Unithroid, Levothroid, Tirosint-Sol
Synonyms: n.a.
Generic Name: rifampin
Brand name: Rifadin, Rifadin IV, Rimactane
Synonyms: Rifampin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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