Noxafil (Posaconazole Oral Suspension) and Varubi (Rolapitant Tablets)
Determining the interaction of Noxafil (Posaconazole Oral Suspension) and Varubi (Rolapitant Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Rolapitant may increase the blood levels and effects of posaconazole. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with rolapitant may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) efflux transporter. When a 0.5 mg dose of digoxin, a P-gp probe substrate, was administered with a 180 mg dose of rolapitant, digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 70% and 30%, respectively.
MANAGEMENT: Caution is advised when rolapitant is prescribed with drugs that are P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever rolapitant is added to or withdrawn from therapy.
- "Product Information. Varubi (rolapitant)." Tesaro Inc., Waltham, MA.
Generic Name: posaconazole
Brand name: Noxafil
Synonyms: Noxafil
Generic Name: rolapitant
Brand name: Varubi
Synonyms: Varubi
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Noxafil (Posaconazole Oral Suspension)-Vaseretic 10-25
- Noxafil (Posaconazole Oral Suspension)-Vaso Dose Pack
- Varubi (Rolapitant Tablets)-Noxafil Intravenous
- Varubi (Rolapitant Tablets)-Noxifol-D
- Varubi (Rolapitant Tablets)-Noxivent
- Varubi (Rolapitant Tablets)-NP Thyroid
- Varubi (Rolapitant Tablets)-NP Thyroid 120
- Varubi (Rolapitant Tablets)-NP Thyroid 15