NP Thyroid 15 and Simvastatin Oral Suspension
Determining the interaction of NP Thyroid 15 and Simvastatin Oral Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Rarely, lovastatin and simvastatin have been reported to reduce the pharmacologic effects of thyroid hormone. The exact mechanism of interaction is unknown. In isolated case reports, patients stabilized on levothyroxine developed symptoms of hypothyroidism and/or elevated thyroid-stimulating hormone (TSH) levels following the addition of lovastatin or simvastatin. Discontinuation of the statin led to resolution of symptoms and normalization of TSH levels. In one case, the patient was subsequently prescribed pravastatin without any adverse effects on his thyroid status. No particular intervention should be necessary when lovastatin or simvastatin is prescribed to patients receiving thyroid hormone therapy, since the interaction appears to be extremely rare. However, thyroid hormone dosage may need to be adjusted if an interaction is suspected. Alternatively, a switch to a statin with a different metabolic profile such as fluvastatin, pravastatin, or rosuvastatin may help.
- Demke DM "Drug interaction between thyroxine and lovastatin." N Engl J Med 321 (1989): 1341-2
- Kisch E, Segall HS "Interaction between simvastatin and L-thyroxine." Ann Intern Med 143 (2005): 547
Generic Name: thyroid desiccated
Brand name: Armour Thyroid, Nature-Throid, Westhroid, Thyroid Porcine, NP Thyroid, WP Thyroid
Synonyms: Thyroid, Desiccated
Generic Name: simvastatin
Brand name: Zocor, Flolipid
Synonyms: Simvastatin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- NP Thyroid 15-Simvastatin orally disintegrating tablet
- NP Thyroid 15-Simvastatin Tablets
- NP Thyroid 15-Sinarest
- NP Thyroid 15-Sinarest Nasal
- NP Thyroid 15-Sinarest Sinus
- NP Thyroid 15-Sine-Off Maximum Strength
- Simvastatin Oral Suspension-NP Thyroid 30
- Simvastatin Oral Suspension-NP Thyroid 60
- Simvastatin Oral Suspension-NP Thyroid 90
- Simvastatin Oral Suspension-NPD Ophthalmic Ointment
- Simvastatin Oral Suspension-Nplate
- Simvastatin Oral Suspension-NRS Nasal