NPD Ophthalmic Ointment and Orfadin

• Generic Name: dexamethasone / neomycin / polymyxin b ophthalmic
• Dosage Forms: ophthalmic ointment
• Other Brand Names: Maxitrol, Ocu-Trol, Poly-Dex, Dexacidin, Dexasporin, Methadex, AK-Trol, Dexacine

Used in conjunction with ventilatory support and other appropriate therapy to improve oxygenation and reduce the need for extracorporeal membrane oxygenation (ECMO) in term or near-term (>34 weeks of age) neonates with hypoxic respiratory failure and clinical or ECG evidence of pulmonary hypertension.

Most effective in patients with severe persistent pulmonary hypertension who have minimal underlying parenchymal lung disease (idiopathic persistent pulmonary hypertension).

Least effective in neonates with pulmonary hypoplasia (e.g., congenital diaphragmatic hernia).

Has been used with good results (i.e., decreased the incidence of severe intraventricular hemorrhage and periventricular leukomalacia) in premature neonates (<34 weeks’ gestation) who were undergoing mechanical ventilation for respiratory distress syndrome.

• Generic Name: nitisinone
• Dosage Forms: capsule
• Other Brand Names: Orfadin, Nityr

Orfadin works by preventing the body from breaking down an amino acid called tyrosine and by keeping other toxic substances from building up and causing harm to your liver or kidneys.

Orfadin is used to treat a rare genetic condition called hereditary tyrosinemia type 1 (HT-1). HT-1 is a metabolic disorder that occurs when the body does not produce enough of an enzyme that breaks down proteins from certain foods. This condition occurs most often in young babies.

Orfadin may also be used for purposes not listed in this medication guide.