Nubeqa and Rosuvastatin Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with darolutamide may significantly increase the plasma concentrations of rosuvastatin. The proposed mechanism is darolutamide inhibition of intestinal and hepatobiliary efflux of rosuvastatin via breast cancer resistance protein (BCRP). When rosuvastatin, a known BCRP substrate, was administered concomitantly with darolutamide, mean rosuvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 5-fold. High levels of HMG-CoA reductase inhibitory activity in plasma may be associated with an increased risk of musculoskeletal toxicity. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death. MANAGEMENT: Concomitant use of rosuvastatin with darolutamide should generally be avoided. If coadministration is required, the lowest effective dosage of rosuvastatin should be used and close monitoring for musculoskeletal toxicity is recommended. Alternatively, a different HMG-CoA reductase inhibitor that is not a substrate for BCRP may be considered. All patients receiving statin therapy should be advised to promptly report any unexplained muscle pain, tenderness or weakness, particularly if accompanied by fever, malaise and/or dark colored urine. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed. References "Product Information. Nubeqa (darolutamide)." Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.

GENERALLY AVOID: Coadministration with darolutamide may significantly increase the plasma concentrations of rosuvastatin. The proposed mechanism is darolutamide inhibition of intestinal and hepatobiliary efflux of rosuvastatin via breast cancer resistance protein (BCRP). When rosuvastatin, a known BCRP substrate, was administered concomitantly with darolutamide, mean rosuvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 5-fold. High levels of HMG-CoA reductase inhibitory activity in plasma may be associated with an increased risk of musculoskeletal toxicity. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death.

MANAGEMENT: Concomitant use of rosuvastatin with darolutamide should generally be avoided. If coadministration is required, the lowest effective dosage of rosuvastatin should be used and close monitoring for musculoskeletal toxicity is recommended. Alternatively, a different HMG-CoA reductase inhibitor that is not a substrate for BCRP may be considered. All patients receiving statin therapy should be advised to promptly report any unexplained muscle pain, tenderness or weakness, particularly if accompanied by fever, malaise and/or dark colored urine. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed.

Nubeqa

Generic Name: darolutamide

Brand name: Nubeqa

Synonyms: n.a.

What is Nubeqa?

Rosuvastatin Tablets

Generic Name: rosuvastatin

Brand name: Crestor, Ezallor Sprinkle

Synonyms: Rosuvastatin

What is Rosuvastatin Tablets?