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Nutropin AQ NuSpin 10 and Pazopanib

Determining the interaction of Nutropin AQ NuSpin 10 and Pazopanib and the possibility of their joint administration.

Check result:
Nutropin AQ NuSpin 10 <> Pazopanib
Relevance: 17.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using PAZOPanib together with somatropin. Combining these medications may decrease the blood levels and effects of PAZOPanib. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations and pharmacologic effects of pazopanib, which is primarily metabolized by the isoenzyme.

MANAGEMENT: The use of pazopanib in combination with potent CYP450 3A4 inducers such as carbamazepine, dexamethasone, enzalutamide, phenobarbital, phenytoin, rifamycins, and St. John's wort should generally be avoided. Alternative treatment lacking CYP450 3A4-inducing activity should be considered in patients receiving pazopanib; otherwise, pazopanib should not be used. Other known CYP450 3A4 inducers include aminoglutethimide, barbiturates, bexarotene, bosentan, dabrafenib, efavirenz, nafcillin, nevirapine, somatrem, somatropin, and various other anticonvulsants, although the extent to which they may interact with pazopanib is unknown.

References
  • "Product Information. Votrient (pazopanib)." GlaxoSmithKline, Research Triangle Park, NC.
Nutropin AQ NuSpin 10

Generic Name: somatropin

Brand name: Genotropin, Humatrope, Norditropin FlexPro Pen, Nutropin AQ NuSpin 10, Nutropin AQ Pen 10 Cartridge, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive, Genotropin Miniquick, Norditropin Nordiflex Pen, Tev-Tropin, Nutropin, Norditropin, Nutropin AQ, Nutropin Depot, Norditropin Cartridge, Saizen Click-Easy, Omnitrope Pen 5 Cartridge, HumatroPen, Omnitrope Pen 10 Cartridge, Nutropin AQ Pen 20 Cartridge, Nutropin AQ NuSpin 5, Nutropin AQ NuSpin 20, Saizen Kit

Synonyms: Nutropin AQ

Pazopanib

Generic Name: pazopanib

Brand name: Votrient

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction