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Obeticholic acid and Zegerid

Determining the interaction of Obeticholic acid and Zegerid and the possibility of their joint administration.

Check result:

Obeticholic acid <> Zegerid

Relevance: 17.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with obeticholic acid may increase the plasma concentrations of omeprazole. The mechanism of interaction has not been described. Omeprazole is primarily metabolized by CYP450 2C19 and 3A4; however, obeticholic acid is not expected to significantly inhibit these pathways at recommended dosages. When a single 20 mg dose of omeprazole was administered with obeticholic acid 10 mg once daily, omeprazole peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 33% and 32%, respectively. The clinical significance is unknown. Conversely, the AUC of obeticholic acid increased by less than 20%, which is not considered clinically relevant. The effect of omeprazole 40 mg once daily with obeticholic acid 10 mg once daily was not studied.

References

"Product Information. Ocaliva (obeticholic acid)." Intercept Pharmaceuticals, Inc., New York, NY.

Obeticholic acid

Generic Name: obeticholic acid

Brand name: Ocaliva

Synonyms: Obeticholic Acid

What is Obeticholic acid?

Zegerid

Generic Name: omeprazole / sodium bicarbonate

Brand name: Zegerid, Zegerid OTC

Synonyms: n.a.

What is Zegerid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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