Octocaine 100 and Rythmol
Determining the interaction of Octocaine 100 and Rythmol and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Propafenone minimally inhibits the hepatic metabolism of lidocaine. Increased plasma concentrations of lidocaine may entail worse nervous system side effects of longer duration. Also, the negative effects these drugs may have on myocardial contractility may be additive. The patient should be monitored for nervous system side effects such as dysgeusia, paresthesias, and light-headedness. During coadministration, hemodynamic status should be monitored and lidocaine dosage should be reduced as necessary.
- Ujhelyi MR, O'Rangers EA, Fan C, Kluger J, Pharand C, Chow MS "The pharmacokinetic and pharmacodynamic interaction between propafenone and lidocaine." Clin Pharmacol Ther 53 (1993): 38-48
- Feld GK, Nademanee K, Singh BN, Kirsten E "Hemodynamic and electrophysiologic effects of combined infusion of lidocaine and propafenone in humans." J Clin Pharmacol 27 (1987): 52-9
Generic Name: epinephrine / lidocaine
Brand name: D-Care 100X, Lignospan Forte, Lignospan Standard, Xylocaine MPF With Epinephrine, Xylocaine With Epinephrine
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Octocaine 100-Rythmol Extended Release
- Octocaine 100-Rythmol SR
- Octocaine 100-Ryvent
- Octocaine 100-Ryzodeg 70/30
- Octocaine 100-Ryzolt
- Rythmol-OctreoScan
- Rythmol-Octreotide
- Rythmol-Octreotide Acetate
- Rythmol-Octreotide injection
- Rythmol-Octreotide Injection, Intramuscular
- Rythmol-Octreotide Long-Acting Injection