Octreotide Injection, Intramuscular and Sandimmune (Cyclosporine Soft Gelatin Capsules)
Determining the interaction of Octreotide Injection, Intramuscular and Sandimmune (Cyclosporine Soft Gelatin Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Octreotide may reduce the blood levels and effects of cycloSPORINE. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with somatostatin analogs may decrease the blood concentrations of cyclosporine. The mechanism of interaction is unknown but may involve reduction of intestinal absorption of cyclosporine. In one case report, a patient with kidney and pancreatic segment transplants receiving azathioprine, methylprednisolone, and cyclosporine experienced a presumed episode of transplant rejection in association with reduced cyclosporine levels shortly after initiation of octreotide therapy. His trough cyclosporine levels fell below the limit of detection while serum creatinine increased dramatically. In other cases, significant reductions in cyclosporine levels, sometimes to undetectable levels, have been reported within 24 to 48 hours after octreotide was initiated. No data are available for lanreotide or pasireotide, although a similar interaction is theoretically possible.
MANAGEMENT: Pharmacologic effects and blood concentrations of cyclosporine should be monitored more closely whenever a somatostatin analog is added to or withdrawn from the patient's anti-rejection regimen, and the cyclosporine dosage adjusted as necessary. The investigators of the case report suggest increasing oral cyclosporine dosage on average by 50% prior to initiating octreotide and monitoring cyclosporine blood levels frequently.
- "Product Information. Neoral Oral Solution (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- Landgraf R, Landgraf-Leurs MM, Nusser J, et al "Effect of somatostatin analogue (SMS201-995) on cyclosporine levels." Transplantation 44 (1987): 724-5
- "Product Information. Somatuline Depot (lanreotide)." Ipsen Inc, Milford, MA.
- "Product Information. Signifor (pasireotide)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: octreotide
Brand name: Sandostatin, Sandostatin LAR Depot
Synonyms: Octreotide (injection), Octreotide
Generic Name: cyclosporine
Brand name: Sandimmune, Gengraf, Neoral, Sandimmune
Synonyms: Sandimmune (Injection), Sandimmune
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Octreotide Injection, Intramuscular-Sandimmune Oral
- Octreotide Injection, Intramuscular-Sandostatin
- Octreotide Injection, Intramuscular-Sandostatin LAR
- Octreotide Injection, Intramuscular-Sandostatin LAR Depot
- Octreotide Injection, Intramuscular-Sandostatin LAR Depot injection
- Octreotide Injection, Intramuscular-Sani-Supp
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Octreotide Long-Acting Injection
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Ocu-Carpine
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Ocu-Chlor
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Ocu-Dex
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Ocu-Disal
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Ocu-Pentolate