Ocufen eent and Phenytoin Sodium

• Generic Name: flurbiprofen ophthalmic
• Dosage Forms: ophthalmic solution
• Other Brand Names: Ocufen

Prophylactically before ocular surgery (e.g., cataract extraction) to prevent or reduce intraoperative miosis.

Has been used for prevention and management of postoperative ocular inflammation associated with argon laser trabeculoplasty and cyclocryotherapy.

Has been used for prevention of postoperative cystoid macular edema associated with cataract extraction.

Has been reported to inhibit corneal neovascularization induced by chemical or thermal burns or prolonged use of contact lenses in preliminary research in animals.

• Generic Name: phenytoin
• Dosage Forms: injection, solution
• Other Brand Names: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt

Management of generalized tonic-clonic (grand mal) seizures.

Management of partial seizures with complex symptomatology (psychomotor and temporal lobe seizures).

Not recommended for treatment of pure absence (petit mal) seizures since the drug may increase frequency of these seizures, but may be used in conjunction with other anticonvulsants when mixed seizure types are present.

Prevention and treatment of seizures occurring during and following neurosurgery.

Used IV for treatment of status epilepticus; however, use may be limited by its slow onset of action and need for slow administration.

Benzodiazepines (e.g., diazepam, lorazepam, midazolam) are considered drugs of choice for initial treatment of status epilepticus; IV phenytoin (or fosphenytoin) may be used as a second-line agent if seizures continue.

Concurrent administration with an IV benzodiazepine or short-acting barbiturate will usually be necessary for rapid control of seizures.

Fosphenytoin appears to be better tolerated than phenytoin, and some experts state that fosphenytoin is preferred when both drugs are available.

Has been used IV for treatment of cardiac arrhythmias, particularly ventricular arrhythmias, in patients who do not respond to conventional antiarrhythmic agents or cardioversion. However, current use as an antiarrhythmic agent is limited by the drug's narrow therapeutic window, multiple drug interactions, and adverse effect profile.

Has been used IV for treatment of arrhythmias caused by cardiac glycoside intoxication, especially in the presence of AV block, because the drug improves conduction through the AV node.