Olanzapine, Olanzapine Pamoate and Pitolisant Hydrochloride
Determining the interaction of Olanzapine, Olanzapine Pamoate and Pitolisant Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: It is uncertain whether olanzapine causes clinically significant prolongation of the QT interval. In pooled studies of adults as well as pooled studies of adolescents, there were no significant differences between olanzapine and placebo in the proportion of patients experiencing potentially important changes in ECG parameters, including QT, QTcF (Fridericia-corrected), and PR intervals. In clinical trials, clinically meaningful QTc prolongations (QTcF >=500 msec at any time post-baseline in patients with baseline QTcF
Professional:MONITOR: It is uncertain whether olanzapine causes clinically significant prolongation of the QT interval. In pooled studies of adults as well as pooled studies of adolescents, there were no significant differences between olanzapine and placebo in the proportion of patients experiencing potentially important changes in ECG parameters, including QT, QTcF (Fridericia-corrected), and PR intervals. In clinical trials, clinically meaningful QTc prolongations (QTcF >=500 msec at any time post-baseline in patients with baseline QTcF
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Zyprexa (olanzapine)." Lilly, Eli and Company, Indianapolis, IN.
Generic Name: olanzapine
Brand name: Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular, Zyprexa Relprevv
Synonyms: Olanzapine, OLANZapine
Generic Name: pitolisant
Brand name: Wakix
Synonyms: Pitolisant
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Olanzapine, Olanzapine Pamoate-Pitressin
- Olanzapine, Olanzapine Pamoate-Pitressin Injection
- Olanzapine, Olanzapine Pamoate-Pitressin Synthetic
- Olanzapine, Olanzapine Pamoate-Placidyl
- Olanzapine, Olanzapine Pamoate-Plan B
- Olanzapine, Olanzapine Pamoate-Plan B One-Step
- Pitolisant Hydrochloride-Olaparib
- Pitolisant Hydrochloride-Olaparib Capsules
- Pitolisant Hydrochloride-Olaparib Tablets
- Pitolisant Hydrochloride-Olaratumab
- Pitolisant Hydrochloride-Olaratumab Intravenous
- Pitolisant Hydrochloride-Oleptro