Olanzapine, Olanzapine Pamoate and Sinemet 10-100
Determining the interaction of Olanzapine, Olanzapine Pamoate and Sinemet 10-100 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:OLANZapine may reduce the effectiveness of levodopa. In addition, using these medications together may increase the risk and/or severity of side effects like drowsiness, low blood pressure, dizziness, and lightheadedness. These effects may occur with either medication alone and are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Agents with central antidopaminergic activity such as phenothiazines, neuroleptics and metoclopramide may antagonize the pharmacologic effects of dopamine agonists. In addition, the central nervous system depressant and hypotensive effects of these agents may be additively or synergistically increased when taken together.
MANAGEMENT: Concomitant use of dopamine agonists with antidopaminergic agents should generally be avoided. If coadministration is necessary, patients should be alerted to the possibility of excessive drowsiness and monitored for potentially diminished therapeutic response to their dopaminergic therapy. Patients treated for Parkinson's disease should generally avoid antidopaminergic agents, particularly phenothiazines and older neuroleptic agents, since these agents may cause extrapyramidal reactions.
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- "Product Information. Permax (pergolide)." Athena Neurosciences Inc, South San Francisco, CA.
- "Product Information. Zyprexa (olanzapine)." Lilly, Eli and Company, Indianapolis, IN.
- "Product Information. Parlodel (bromocriptine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Generic Name: olanzapine
Brand name: Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular, Zyprexa Relprevv
Synonyms: Olanzapine, OLANZapine
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: Carbidopa and levodopa, Carbidopa and Levodopa
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Olanzapine, Olanzapine Pamoate-Sinemet 25-250
- Olanzapine, Olanzapine Pamoate-Sinemet 250/25
- Olanzapine, Olanzapine Pamoate-Sinemet CR
- Sinemet 10-100-Olaparib
- Sinemet 10-100-Olaparib Capsules
- Sinemet 10-100-Olaparib Tablets
- Sinemet 10-100-Olaratumab
- Sinemet 10-100-Olaratumab Intravenous
- Sinemet 10-100-Oleptro