Ombitasvir, paritaprevir, ritonavir and dasabuvir and Omeprazole Delayed-Release Capsules and Tablets (OTC)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Paritaprevir may reduce the blood levels of omeprazole, which may make the medication less effective in treating your condition. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with ombitasvir/paritaprevir/ritonavir plus dasabuvir may decrease the plasma concentrations of omeprazole. The proposed mechanism of interaction is CYP450 2C19 induction by ritonavir. In 11 study subjects, administration of omeprazole 40 mg once daily in combination with once daily doses of ombitasvir/paritaprevir/ritonavir (25 mg/150 mg/100 mg) plus twice daily doses of dasabuvir resulted in approximately 38% decreases in both mean omeprazole peak plasma concentration (Cmax) and systemic exposure (AUC). The pharmacokinetics of ombitasvir, paritaprevir, ritonavir, and dasabuvir were not significantly altered. This interaction may also be expected with the other proton pump inhibitors, which are also CYP450 2C19 substrates; however, data are lacking.

MANAGEMENT: Patients should be monitored for potentially diminished efficacy of omeprazole during coadministration with ombitasvir/paritaprevir/ritonavir plus dasabuvir. The dosage of omeprazole may be increased in patients whose symptoms are not well controlled; however, some authorities suggest that the dosage of omeprazole should be limited to 40 mg/day.

Ombitasvir, paritaprevir, ritonavir and dasabuvir

Generic Name: dasabuvir / ombitasvir / paritaprevir / ritonavir

Brand name: Viekira XR, Viekira Pak

Synonyms: Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets, and Dasabuvir

What is Ombitasvir, paritaprevir, ritonavir and dasabuvir?

Omeprazole Delayed-Release Capsules and Tablets (OTC)

Generic Name: omeprazole

Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Zegerid>, Prilosec, Prilosec OTC

Synonyms: Omeprazole

What is Omeprazole Delayed-Release Capsules and Tablets (OTC)?