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Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Tablets and Viramune Suspension

Determining the interaction of Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Tablets and Viramune Suspension and the possibility of their joint administration.

Check result:

Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Tablets <> Viramune Suspension

Relevance: 21.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using paritaprevir together with nevirapine is not recommended. Combining these medications may significantly reduce the blood levels of paritaprevir, which may make the medication less effective in treating hepatitis C. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with moderate to potent inducers of CYP450 isoenzymes may significantly decrease the plasma concentrations of ombitasvir, paritaprevir, and dasabuvir. The proposed mechanism may involve induction of CYP450 3A4.

MANAGEMENT: Concomitant use of CYP450 3A4 inducers such etravirine or nevirapine with ombitasvir/paritaprevir/ritonavir with or without dasabuvir is considered contraindicated by some authorities.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Department of Health and Human Services "Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Available from: URL: https://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultAndAdolescentGL.pdf." ([2015, April 8]):
Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
"Product Information. Viekira Pak (dasabuvir/ombitasvir/paritaprevir/ritonavir)." AbbVie US LLC, North Chicago, IL.

Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Tablets

Generic Name: dasabuvir / ombitasvir / paritaprevir / ritonavir

Brand name: Viekira XR, Viekira Pak

Synonyms: Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets, and Dasabuvir

What is Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Tablets?

Viramune Suspension

Generic Name: nevirapine

Brand name: Viramune, Viramune XR

Synonyms: Viramune

What is Viramune Suspension?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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