Omeprazole and Sodium Bicarbonate Capsules and Valdecoxib
Determining the interaction of Omeprazole and Sodium Bicarbonate Capsules and Valdecoxib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with valdecoxib or its prodrug, parecoxib, may increase the plasma concentrations of omeprazole. The mechanism is valdecoxib inhibition of CYP450 2C19 and 3A4, the isoenzymes responsible for the metabolic clearance of omeprazole. According to product labeling, coadministration of valdecoxib (40 mg twice a day) and omeprazole (40 mg once a day) resulted in a 46% increase in the systemic exposure (AUC) of omeprazole compared to administration of omeprazole alone. The pharmacokinetics of valdecoxib were not significantly affected. Because higher dosages (up to 360 mg/day) of omeprazole are tolerated in Zollinger-Ellison patients, no dosage adjustment for omeprazole is indicated at normally recommended dosages. However, drugs whose absorption is sensitive to pH (e.g., some cephalosporins such as cefditoren, cefpodoxime, and cefuroxime; antiretroviral agents including atazanavir, delavirdine, and fosamprenavir; cyanocobalamin; ketoconazole; enteric coated preparations) may be negatively impacted by concomitant administration of omeprazole and valdecoxib or parecoxib. Coadministration of valdecoxib with dosages of omeprazole higher than 40 mg/day has not been studied.
- "Product Information. Bextra (valdecoxib)." Pharmacia Corporation, Peapack, NJ.
Generic Name: omeprazole / sodium bicarbonate
Brand name: Zegerid, Zegerid OTC
Synonyms: Omeprazole and sodium bicarbonate, Omeprazole and Sodium Bicarbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Omeprazole and Sodium Bicarbonate Capsules-Valerian
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- Omeprazole and Sodium Bicarbonate Capsules-Valganciclovir
- Omeprazole and Sodium Bicarbonate Capsules-Valganciclovir Hydrochloride
- Omeprazole and Sodium Bicarbonate Capsules-Valganciclovir Oral Solution
- Omeprazole and Sodium Bicarbonate Capsules-Valganciclovir Solution
- Valdecoxib-Omeprazole and Sodium Bicarbonate Powder Packets
- Valdecoxib-Omeprazole Delayed-Release Capsules
- Valdecoxib-Omeprazole Delayed-Release Capsules and Tablets (OTC)
- Valdecoxib-Omeprazole Orally-Disintegrating Tablets
- Valdecoxib-Omeprazole Powder for Oral Suspension
- Valdecoxib-Omeprazole Tablets