Omeprazole Delayed-Release Capsules and Ponatinib
Determining the interaction of Omeprazole Delayed-Release Capsules and Ponatinib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with drugs that elevate the gastric pH such as proton pump inhibitors, H2-receptor antagonists, and antacids may decrease the oral bioavailability of ponatinib and reduce its concentrations in plasma. The aqueous solubility of ponatinib has been shown to be pH-dependent, with higher pH resulting in decreased solubility. However, in a drug interaction study in healthy volunteers, coadministration of ponatinib after multiple doses of lansoprazole resulted in a minor reduction in ponatinib Cmax but no change in overall systemic exposure (AUC) compared to ponatinib administered alone. Therefore, ponatinib may be coadministered with medicines that increase gastric pH without dose adjustment or separation of administration.
- "Product Information. Iclusig (ponatinib)." Ariad Pharmaceuticals Inc, Cambridge, MA.
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: omeprazole
Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Zegerid>, Prilosec, Prilosec OTC
Synonyms: Omeprazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Omeprazole Delayed-Release Capsules-Ponstel
- Omeprazole Delayed-Release Capsules-Pontocaine
- Omeprazole Delayed-Release Capsules-Pontocaine HCl
- Omeprazole Delayed-Release Capsules-Porfimer
- Omeprazole Delayed-Release Capsules-Porfimer Intravenous
- Omeprazole Delayed-Release Capsules-Portia
- Ponatinib-Omeprazole Delayed-Release Capsules and Tablets (OTC)
- Ponatinib-Omeprazole Orally-Disintegrating Tablets
- Ponatinib-Omeprazole Powder for Oral Suspension
- Ponatinib-Omeprazole Tablets
- Ponatinib-Omeprazole, Clarithromycin, and Amoxicillin
- Ponatinib-Omidria