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Omeprazole Delayed-Release Capsules and Riluzole

Determining the interaction of Omeprazole Delayed-Release Capsules and Riluzole and the possibility of their joint administration.

Check result:
Omeprazole Delayed-Release Capsules <> Riluzole
Relevance: 01.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Omeprazole may decrease the serum concentration of riluzole. Riluzole is metabolized by the CYP450 1A2 isoenzyme. Omeprazole may induce this particular isoenzyme, possibly increasing the riluzole elimination rate. The clinical significance of this interaction is not known. During coadministration, the patient should be more closely monitored for altered clinical effect.

References
  • "Product Information. Rilutek (riluzole)." Rhone-Poulenc Rorer, Collegeville, PA.
Omeprazole Delayed-Release Capsules

Generic Name: omeprazole

Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Zegerid>, Prilosec, Prilosec OTC

Synonyms: Omeprazole

Riluzole

Generic Name: riluzole

Brand name: Rilutek, Tiglutik

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle