Omeprazole Delayed-Release Capsules and Vosevi

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Depending on the dose, omeprazole may interfere with the absorption of velpatasvir and reduce its effectiveness. Talk to your doctor or pharmacist if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment of omeprazole to safely use both medications. You should take velpatasvir with food and at least 4 hours before the dose of omeprazole. Contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration of velpatasvir with proton pump inhibitors may reduce its gastrointestinal absorption. Velpatasvir exhibits pH-dependent solubility, with increased solubility at lower pH. In 60 healthy volunteers, mean velpatasvir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 37% and 36%, respectively, when a single 400 mg-100 mg dose of sofosbuvir-velpatasvir was administered simultaneously with omeprazole 20 mg once daily. Interestingly, mean sofosbuvir Cmax and AUC also decreased by 34% and 29%, respectively, although its solubility is not known to be pH-dependent. When omeprazole 20 mg once daily was given 12 hours before the sofosbuvir-velpatasvir dose, mean velpatasvir Cmax and AUC decreased by 57% and 55%, respectively, while mean sofosbuvir Cmax and AUC decreased by 45% and 44%, respectively. Similar results were observed for velpatasvir when omeprazole 20 mg once daily was given 2 hours before the sofosbuvir-velpatasvir dose, or when omeprazole 40 mg once daily was given 4 hours after the sofosbuvir-velpatasvir dose. When omeprazole 20 mg once daily was administered 4 hours after the sofosbuvir-velpatasvir dose, mean velpatasvir Cmax decreased by 33% and AUC decreased by 26%.

MANAGEMENT: Concomitant use of sofosbuvir-velpatasvir with proton-pump inhibitors should generally be avoided. If coadministration is required, sofosbuvir-velpatasvir should be administered with food and taken 4 hours before the proton-pump inhibitor at a maximum daily dose equivalent to omeprazole 20 mg. Use with other proton-pump inhibitors has not been studied.

Omeprazole Delayed-Release Capsules

Generic Name: omeprazole

Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Zegerid>, Prilosec, Prilosec OTC

Synonyms: Omeprazole

What is Omeprazole Delayed-Release Capsules?

Vosevi

Generic Name: sofosbuvir / velpatasvir / voxilaprevir

Brand name: Vosevi

Synonyms: n.a.

What is Vosevi?