Omnipaque 12 and Sotalol Hydrochloride
Determining the interaction of Omnipaque 12 and Sotalol Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before you undergo any imaging procedure where iohexol may be given by injection, let your doctor know if you are currently being treated with sotalol. Injection of iohexol can sometimes cause severe allergic reactions and low blood pressure, and the risk may be increased if you are also using sotalol. In addition, treatment of the allergic reactions may be more difficult if medications like sotalol are present in the body. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited data suggest that patients receiving beta-blockers may have an increased risk of severe hypotensive and/or hypersensitivity reactions to parenteral iodinated contrast media. In addition, allergic/anaphylactoid reactions in these patients may be more difficult to treat. The mechanism is unknown. Theoretically, beta-blocker ophthalmic solutions may also interact, as they are systemically absorbed and can produce clinically significant systemic effects even at low or undetectable plasma levels.
MANAGEMENT: Patients who have received beta-blockers should be closely monitored for adverse reactions to iodinated contrast media. If anaphylaxis occurs, clinicians should be aware that beta-blockers may attenuate the response to epinephrine. Thus, larger doses of epinephrine may be necessary to overcome the bronchospasm, although such large doses can also cause excessive alpha-adrenergic stimulation resulting in hypertension, reflex bradycardia, heart block, and possible potentiation of bronchospasm. Alternative treatments recommended include vigorous supportive care (e.g., fluids) and the use of parenteral beta-agonists for bronchospasm and norepinephrine for hypotension.
- Costa N "Understanding contrast media." J Infus Nurs 27 (2004): 302-12
- "Product Information. Visipaque (iodixanol)." Nycomed Inc, Princeton, NJ.
- "Product Information. Ultravist (iopromide)." Berlex, Richmond, CA.
- "Product Information. Osmovist 240 (iotrolan)." Berlex Canada Inc, Lachine, QC.
Generic Name: iohexol
Brand name: Omnipaque
Synonyms: Omnipaque 12 (Oral)
Generic Name: sotalol
Brand name: Betapace, Betapace AF, Sorine, Sotalol Hydrochloride AF, Sotylize
Synonyms: Sotalol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Omnipaque 12-Sotalol Injection
- Omnipaque 12-Sotalol Intravenous
- Omnipaque 12-Sotalol Oral Solution
- Omnipaque 12-Sotalol Tablets
- Omnipaque 12-Sotret
- Omnipaque 12-Sotylize
- Sotalol Hydrochloride-Omnipaque 9
- Sotalol Hydrochloride-Omnipaque Injection
- Sotalol Hydrochloride-Omnipen-N injection
- Sotalol Hydrochloride-Omnipred
- Sotalol Hydrochloride-Omnipred ophthalmic
- Sotalol Hydrochloride-Omniscan