Oncaspar and Venclexta

• Generic Name: pegaspargase
• Dosage Forms: injection, solution
• Other Brand Names: Oncaspar

Oncaspar is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Oncaspar is used in combination with other cancer medications to treat acute lymphoblastic leukemia. Oncaspar is also used to treat allergic reactions to another cancer medication called asparaginase (Elspar).

Oncaspar may also be used for purposes not listed in this medication guide.

• Generic Name: venetoclax
• Dosage Forms: tablets
• Other Brand Names: Venclexta, Venclexta Starting Pack

Venclexta (venetoclax) inhibits a certain protein in cancer cells (abnormal lymphocytes produced in chronic lymphocytic leukemia) that helps keep those cells alive and makes them resistant to chemotherapy. Venetoclax binds to this protein, which helps kill the cancerous lymphocytes in blood and bone marrow.

Venclexta is used to treat chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL) in adults with or without 17p deletion (a specific genetic marker). Venclexta is sometimes used in combination with rituximab to treat these conditions.

Venclexta is also used in combination with azacitidine, decitabine, or cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.

Venclexta is sometimes given after other treatments have failed.