Onfi (Clobazam Tablets) and Stiripentol Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Stiripentol may significantly increase the blood levels of cloBAZam. This may increase side effects such as dizziness, drowsiness, difficulty concentrating, and impairment in thinking and motor skills. You may need a dose adjustment or more frequent monitoring to safely use both medications. You should avoid or limit the use of alcohol while being treated with these medications. Also, avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with stiripentol may significantly increase the plasma concentrations of clobazam and its pharmacologically active metabolite, norclobazam. The proposed mechanism is stiripentol inhibition of CYP450 3A4 and CYP450 2C19, the isoenzymes responsible for the metabolic clearance of clobazam and norclobazam, respectively. In pediatric patients, addition of stiripentol to clobazam increased plasma concentrations of clobazam by 2- to 3-fold and norclobazam by 5-fold. Although stiripentol is approved for use with clobazam in the treatment of Dravet syndrome, concomitant use may increase clobazam-related adverse effects such as somnolence and impairment of judgment, thinking, and psychomotor skills. Clobazam does not appear to significantly affect the pharmacokinetics of stiripentol. An average increase of 25% in stiripentol concentration has been reported during coadministration with clobazam in a retrospective analysis of 220 stiripentol concentrations from 75 patients.

MANAGEMENT: Patients should be closely monitored for clobazam adverse effects, particularly somnolence, during coadministration with stiripentol. A dosage reduction of clobazam by 25% should be considered upon onset of side effects, followed by additional reductions of 25% if side effects persist. In clinical studies, the daily dosage of clobazam was decreased by 25% every week in subjects who exhibited side effects or signs of excessive dosage such as drowsiness, hypotonia, and irritability (in young children). Adjustment of other concomitant anticonvulsant drugs with sedating properties may also be required. Patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them.

Onfi (Clobazam Tablets)

Generic Name: clobazam

Brand name: Onfi, Sympazan

Synonyms: Onfi, Onfi Tablets

What is Onfi (Clobazam Tablets)?

Stiripentol Capsules

Generic Name: stiripentol

Brand name: Diacomit

Synonyms: Stiripentol

What is Stiripentol Capsules?