Orenitram and Soliris

• Generic Name: treprostinil
• Dosage Forms: tablet, extended release
• Other Brand Names: Orenitram, Remodulin, Tyvaso, Tyvaso Refill Kit, Tyvaso Starter Kit

Orenitram (treprostinil) dilates (widens) the arteries and decreases the amount of blood clotting platelets in your body. These effects lower blood pressure in the pulmonary artery that leads from the heart to the lungs.

Orenitram is used to treat pulmonary arterial hypertension (PAH). This medicine improves your ability to exercise.

Orenitram may also be used for purposes not listed in this medication guide.

• Generic Name: eculizumab
• Dosage Forms: injection, solution, concentrate
• Other Brand Names: Soliris

Soliris (eculizumab) is a monoclonal antibody. Eculizumab binds to proteins in the blood that can destroy red blood cells in people with genetic conditions that affect the natural defenses of red blood cells.

Soliris is used to prevent the breakdown of red blood cells in adults with paroxysmal nocturnal hemoglobinuria (PNH).

Soliris is also used to treat a rare chronic blood disease called atypical hemolytic uremic syndrome (aHUS) in adults and children who weigh at least 11 pounds (5 kilograms).

Soliris is also used to treat myasthenia gravis in adults.

Soliris is also used to treat neuromyelitis optica spectrum disorder (NMOSD) in adults.

Soliris is available only under a special program. You must be registered in the program and understand the risks and benefits of this medicine.