Orkambi and Procardia XL

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.GENERALLY AVOID: Potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of calcium channel blockers, the majority of which are primarily metabolized by the isoenzyme. Undetectable plasma levels have been reported for some calcium blockers when given orally. MANAGEMENT: Concomitant use of calcium channel blockers with potent CYP450 3A4 inducers should generally be avoided. However, if concomitant use is necessary, dosage adjustments as well as close monitoring of pharmacologic effects, particularly blood pressure, should be considered whenever a potent CYP450 3A4 inducer is added to or withdrawn from therapy. References "Product Information. Rifadin (rifampin)." Hoechst Marion-Roussel Inc, Kansas City, MO. "Product Information. Mycobutin (rifabutin)." Pharmacia and Upjohn, Kalamazoo, MI. Tada Y, Tsuda Y, Otsuka T, et al "Case report: nifedipine-rifampicin interaction attenuates the effect on blood pressure in a patient with essential hypertension." Am J Med Sci 303 (1992): 25-7

GENERALLY AVOID: Potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of calcium channel blockers, the majority of which are primarily metabolized by the isoenzyme. Undetectable plasma levels have been reported for some calcium blockers when given orally.

MANAGEMENT: Concomitant use of calcium channel blockers with potent CYP450 3A4 inducers should generally be avoided. However, if concomitant use is necessary, dosage adjustments as well as close monitoring of pharmacologic effects, particularly blood pressure, should be considered whenever a potent CYP450 3A4 inducer is added to or withdrawn from therapy.

Orkambi

Generic Name: ivacaftor / lumacaftor

Brand name: Orkambi

Synonyms: n.a.

What is Orkambi?

Procardia XL

Generic Name: nifedipine

Brand name: Adalat CC, Procardia, Procardia XL, Afeditab CR, Nifediac CC, Nifedical XL, Adalat

Synonyms: n.a.

What is Procardia XL?