Orphenadrine, aspirin, and caffeine and Trifluridine and Tipiracil Hydrochloride

• Generic Name: aspirin / caffeine / orphenadrine
• Dosage Forms: tablet
• Other Brand Names: Norgesic Forte, Orphengesic Forte, Norgesic, Orphengesic

Orphenadrine and aspirin combination is used to help relax certain muscles in your body and relieve the pain and discomfort caused by strains, sprains, or other injury to your muscles. However, orphenadrine, aspirin, and caffeine does not take the place of rest, exercise, or other treatment that your doctor may recommend for your medical problem.

Orphenadrine acts in the central nervous system (CNS) to produce its muscle relaxant effects. Actions in the CNS may also be responsible for some of its side effects. Orphenadrine also has other actions (antimuscarinic) that may be responsible for some of its side effects.

This combination medicine also contains caffeine.

In the U.S., this combination medicine is available only with your doctor's prescription.

• Generic Name: tipiracil / trifluridine
• Dosage Forms: n.a.
• Other Brand Names: Lonsurf

Treatment of metastatic colorectal cancer previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-containing regimens; a vascular endothelial growth factor inhibitor (anti-VEGF therapy); and, in patients with tumors bearing wild-type (nonmutated) KRAS gene, an epidermal growth factor receptor inhibitor (anti-EGFR therapy).