Orphenadrine Citrate and Siltuximab

• Generic Name: orphenadrine
• Dosage Forms: n.a.
• Other Brand Names: Norflex, Banflex, Orphenate, Flexoject, Flexon, Mio-Rel, Myolin, Orfro, Norflex Injectable, Antiflex

Used alone or in combination with aspirin and caffeine as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.

If pharmacologic therapy is required for acute low back pain (usually a benign and self-limiting condition ), an analgesic (e.g., acetaminophen, NSAIA) generally is recommended. Skeletal muscle relaxants may be used alone or in combination with analgesics for short-term relief; however, consider high incidence of adverse effects (e.g., CNS effects). Use skeletal muscle relaxants with caution and weigh risks against benefits.

Various skeletal muscle relaxants appear to have comparable efficacy for low back pain relief.

• Generic Name: siltuximab
• Dosage Forms: n.a.
• Other Brand Names: Sylvant

Siltuximab is used to treat Multicentric Castleman's Disease (MCD). MCD is a rare condition in which the body produces too much of a certain type of white blood cell. MCD can increase your risk of certain cancers by changing the way your immune system works.

Siltuximab is not for use in people who have human immunodeficiency virus (HIV) or human herpesvirus-8.

Siltuximab may also be used for purposes not listed in this medication guide.