Osimertinib and Probenecid and colchicine
Determining the interaction of Osimertinib and Probenecid and colchicine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Osimertinib may alter the blood levels and effects of colchicine. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with osimertinib may alter the plasma concentrations of drugs that are primarily metabolized by CYP450 3A4. In vitro, osimertinib has been shown to be a competitive inhibitor as well as inducer of CYP450 3A4. However, no pharmacokinetic data are available from drug interaction studies.
MANAGEMENT: Concomitant use of osimertinib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. These drugs include, but are not limited to: alfentanil, cisapride, colchicine, cyclosporine, fentanyl, ivacaftor, lovastatin, simvastatin, oral midazolam, triazolam, pimozide, quinidine, sildenafil, ergot derivatives, macrolide immunosuppressants, and vinca alkaloids.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Tagrisso (osimertinib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: colchicine / probenecid
Brand name:
Synonyms: Probenecid and colchicine (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Osimertinib-Probenecid Tablets
- Osimertinib-Probiotic Formula (Bacillus Coagulans)
- Osimertinib-Probucol
- Osimertinib-Probuphine
- Osimertinib-Procainamide
- Osimertinib-Procainamide capsules
- Probenecid and colchicine-Osimertinib Mesylate
- Probenecid and colchicine-Osmitrol
- Probenecid and colchicine-Osmolex ER
- Probenecid and colchicine-OsmoPrep
- Probenecid and colchicine-OsmoPrep Oral
- Probenecid and colchicine-Ospemifene