Osimertinib and Zyprexa Intramuscular

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Osimertinib may reduce the blood levels and effects of OLANZapine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with osimertinib may decrease the plasma concentrations of drugs that are primarily metabolized by CYP450 1A2. In vitro, osimertinib has been shown to be an inducer of the isoenzyme. However, no pharmacokinetic data are available from drug interaction studies.

MANAGEMENT: Caution is advised when osimertinib is prescribed with drugs that undergo metabolism by CYP450 1A2. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever osimertinib is added to or withdrawn from therapy. Sensitive CYP450 1A2 substrates or substrates with narrow therapeutic ranges (e.g., theophylline) should preferably be avoided with osimertinib, if possible.

Osimertinib

Generic Name: osimertinib

Brand name: Tagrisso

Synonyms: n.a.

What is Osimertinib?

Zyprexa Intramuscular

Generic Name: olanzapine

Brand name: Zyprexa Intramuscular, Zyprexa, Zyprexa Zydis, Zyprexa Relprevv

Synonyms: n.a.

What is Zyprexa Intramuscular?