Osimertinib Mesylate and Sufentanil Injection
Determining the interaction of Osimertinib Mesylate and Sufentanil Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Osimertinib may alter the blood levels and effects of SUFentanil. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with osimertinib may alter the plasma concentrations of drugs that are primarily metabolized by CYP450 3A4. In vitro, osimertinib has been shown to be a competitive inhibitor as well as inducer of CYP450 3A4. However, no pharmacokinetic data are available from drug interaction studies.
MANAGEMENT: Concomitant use of osimertinib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. These drugs include, but are not limited to: alfentanil, cisapride, colchicine, cyclosporine, fentanyl, ivacaftor, lovastatin, simvastatin, oral midazolam, triazolam, pimozide, quinidine, sildenafil, ergot derivatives, macrolide immunosuppressants, and vinca alkaloids.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Tagrisso (osimertinib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: osimertinib
Brand name: Tagrisso
Synonyms: Osimertinib
Generic Name: sufentanil
Brand name: Dsuvia
Synonyms: Sufentanil Sublingual Tablets, SUFentanil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Osimertinib Mesylate-Sufentanil Sublingual Tablets
- Osimertinib Mesylate-Sugammadex
- Osimertinib Mesylate-Sugammadex Intravenous
- Osimertinib Mesylate-Sugammadex Sodium
- Osimertinib Mesylate-Sul-Ray Aloe Vera Acne Topical
- Osimertinib Mesylate-Sular
- Sufentanil Injection-Osmitrol
- Sufentanil Injection-Osmolex ER
- Sufentanil Injection-OsmoPrep
- Sufentanil Injection-OsmoPrep Oral
- Sufentanil Injection-Ospemifene
- Sufentanil Injection-Osphena