Osimertinib Mesylate and Tekamlo

• Generic Name: osimertinib
• Dosage Forms: n.a.
• Other Brand Names: Tagrisso

First-line treatment of metastatic NSCLC in patients with epidermal growth factor receptor (EGFR) exon 19 deletions (del19) or exon 21 (L858R) substitution mutations (as detected by an FDA-approved diagnostic test).

Treatment of metastatic NSCLC in patients with EGFR T790M mutation (as detected by an FDA-approved diagnostic test) who have experienced disease progression during or after EGFR tyrosine kinase inhibitor therapy.

Designated an orphan drug by FDA for treatment of EGFR mutation-positive NSCLC.

• Generic Name: aliskiren / amlodipine
• Dosage Forms: tablet, film coated
• Other Brand Names: Tekamlo

Tekamlo contains a combination of aliskiren and amlodipine. Aliskiren is an anti-hypertensive (blood pressure lowering) medication. It works by decreasing substances in the body that narrow blood vessels and raise blood pressure.

Amlodipine belongs to a group of medicines called calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Tekamlo is used to treat high blood pressure (hypertension).

Tekamlo may also be used for purposes not listed in this medication guide.