Osimertinib Mesylate and Zonacort Tablets
Determining the interaction of Osimertinib Mesylate and Zonacort Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dexamethasone may reduce the blood levels of osimertinib, which may make the medication less effective in some cases. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of osimertinib, which has been shown in vitro to be primarily metabolized by the isoenzyme. Reduced therapeutic efficacy of osimertinib may occur. However, no pharmacokinetic data are available from drug interaction studies.
MANAGEMENT: The potential for diminished pharmacologic effects of osimertinib should be considered during coadministration with CYP450 3A4 inducers. Alternative treatments may be required if an interaction is suspected.
- "Product Information. Tagrisso (osimertinib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: osimertinib
Brand name: Tagrisso
Synonyms: Osimertinib
Generic Name: dexamethasone
Brand name: Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Osimertinib Mesylate-Zonalon
- Osimertinib Mesylate-Zonalon Topical
- Osimertinib Mesylate-Zonatuss
- Osimertinib Mesylate-Zonegran
- Osimertinib Mesylate-Zonisamide
- Osimertinib Mesylate-Zonisamide Capsules
- Zonacort Tablets-Osmitrol
- Zonacort Tablets-Osmolex ER
- Zonacort Tablets-OsmoPrep
- Zonacort Tablets-OsmoPrep Oral
- Zonacort Tablets-Ospemifene
- Zonacort Tablets-Osphena