Ospemifene and Robitussin Cold Cough and Flu
Determining the interaction of Ospemifene and Robitussin Cold Cough and Flu and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ospemifene may increase the blood levels and effects of acetaminophen. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Ospemifene and its major metabolite, 4-hydroxyospemifene, may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of organic cation transporter (OCT)1, uridine diphosphate glucuronosyltransferase (UGT) 1A3, and/or UGT1A9. The proposed mechanism, based on in vitro data, is decreased clearance due to ospemifene-mediated inhibition of OCT1, UGT1A3, and/or UGT1A9.
MANAGEMENT: Until more information is available, caution is advised when ospemifene is used concomitantly with drugs that are substrates of OCT1, UGT1A3, and/or UGT1A9, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever ospemifene is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine
Brand name: Duraflu, Robitussin Cold Cough and Flu, Theraflu Max-D Severe Cold & Flu, Sudafed Cold and Cough Liquicaps, Theraflu Chest and Cough, Tylenol Cold Severe Congestion Non-Drowsy, Sudafed Sinus and Cold Liquicaps, Phlemgesic, Maxiflu DM, Flutabs, Tylenol Cold Severe Congestion
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ospemifene-Robitussin Cough & Allergy
- Ospemifene-Robitussin Cough + Chest Congestion DM
- Ospemifene-Robitussin CoughGels
- Ospemifene-Robitussin DM
- Ospemifene-Robitussin Flu
- Ospemifene-Robitussin Honey Flu Non-Drowsy
- Robitussin Cold Cough and Flu-Osphena
- Robitussin Cold Cough and Flu-Osteo Bi-Flex
- Robitussin Cold Cough and Flu-Osteo Bi-Flex Advanced MSM
- Robitussin Cold Cough and Flu-Osteo Bi-Flex Plus MSM
- Robitussin Cold Cough and Flu-Otezla
- Robitussin Cold Cough and Flu-Oti-Sone