Osphena and Tegretol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may decrease the blood levels and effects of ospemifene. Contact your doctor if your condition worsens or ospemifene is no longer controlling your symptoms. Your doctor may be able to prescribe alternative treatments that do not interact, or you may need a dose adjustment to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with potent inducers of CYP450 3A4, 2C9, and/or 2C19 may decrease the plasma concentrations of ospemifene, which is metabolized by these isoenzymes. The interaction has been studied with rifampin, a potent CYP450 3A4/moderate CYP450 2C9/moderate CYP450 2C19 inducer. In 12 postmenopausal women pretreated with rifampin 600 mg once daily for 5 days, administration of ospemifene 60 mg after breakfast on day 6 resulted in 51% and 58% decreases in ospemifene peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to administration of ospemifene alone.

MANAGEMENT: The potential for reduced therapeutic effects of ospemifene should be considered when used in combination with potent inducers of CYP450 3A4, 2C9, and/or 2C19.

Osphena

Generic Name: ospemifene

Brand name: Osphena

Synonyms: n.a.

What is Osphena?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?