Otrexup injection and Pegaspargase Intramuscular, Intravenous
Determining the interaction of Otrexup injection and Pegaspargase Intramuscular, Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Pegaspargase may reduce the effects of methotrexate in the treatment of some conditions. The interaction may occur even if you are receiving methotrexate after you have stopped treatment with pegaspargase, as there may be residual low levels of the drug in your system. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Nonclinical data suggest that the concomitant use of L-asparaginase and methotrexate may reduce the antineoplastic effect of methotrexate. The mechanism and clinical significance are unknown.
MANAGEMENT: It is recommended to avoid concomitant or sequential use while plasma asparagine levels are below normal.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: methotrexate
Brand name: Methotrexate Sodium, Preservative Free, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep
Synonyms: Otrexup (injection), Otrexup
Generic Name: pegaspargase
Brand name: Oncaspar
Synonyms: Pegaspargase
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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