Oxacillin Sodium and Protein C Concentrate

• Generic Name: oxacillin
• Dosage Forms: n.a.
• Other Brand Names:

  Oxacillin Sodium ADD-Vantage, Bactocill

Treatment of infections caused by, or suspected of being caused by, susceptible penicillinase-producing staphylococci, including respiratory tract, skin and skin structure, bone and joint, and urinary tract infections and meningitis or bacteremia. A drug of choice for these infections.

Treatment of native valve or prosthetic valve endocarditis caused by susceptible staphylococci. A drug of choice; used with or without gentamicin for native valve endocarditis and used in conjunction with rifampin and gentamicin for prosthetic valve endocarditis.

If used empirically, consider whether staphylococci resistant to penicillinase-resistant penicillins (oxacillin-resistant [methicillin-resistant] staphylococci) are prevalent in the hospital or community. (See Staphylococci Resistant to Penicillinase-resistant Penicillins under Cautions.)

Has been used for perioperative prophylaxis in patients undergoing neurosurgery or cardiovascular or orthopedic surgery associated with high risk of staphylococcal infections. Not considered a drug of choice.

• Generic Name: protein c
• Dosage Forms: n.a.
• Other Brand Names: Ceprotin

Replacement therapy in patients with severe congenital protein C deficiency for prevention and treatment of venous thrombosis and purpura fulminans (designated an orphan drug by FDA for this use).