Oxtriphylline and guaifenesin and Procardia XL
Determining the interaction of Oxtriphylline and guaifenesin and Procardia XL and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited and controversial data suggest the following: either there is no significant interaction between theophylline and dihydropyridine calcium channel blockers, or theophylline serum levels increase after the addition of dihydropyridine calcium channel blockers. Data are available for nifedipine. Theophylline dosage should be reduced if necessary, and plasma levels should be checked when clinically necessary and appropriate. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physician.
- Parrillo SJ, Venditto M "Elevated theophylline blood levels from institution of nifedipine therapy." Ann Emerg Med 13 (1984): 216-7
- Harrod CS "Theophylline toxicity and nifedipine." Ann Intern Med 106 (1987): 480
- Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50
Generic Name: guaifenesin / oxtriphylline
Brand name:
Synonyms: Oxtriphylline and guaifenesin (Oral)
Generic Name: nifedipine
Brand name: Adalat CC, Procardia, Procardia XL, Afeditab CR, Nifediac CC, Nifedical XL, Adalat
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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