Oxtriphylline and guaifenesin and Propafenone Sustained-Release Capsules
Determining the interaction of Oxtriphylline and guaifenesin and Propafenone Sustained-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using oxtriphylline together with propafenone may increase the effects of oxtriphylline. Contact your doctor if you experience nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, and seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Propafenone may inhibit the clearance of theophyllines. The exact mechanism is not known. Serum theophylline concentration and the risk of toxicity may be increased. Patients with chronic obstructive pulmonary disease, congestive heart failure, or cirrhosis may have slower theophylline clearance rates; therefore, they may be at greater risk of developing theophylline toxicity. Also, the clinician should be aware of the risk that bronchospasm may be induced or exacerbated by propafenone. These drugs may have antagonistic pharmacologic effects on the patient's airways.
MANAGEMENT: If these drugs are given concurrently, close clinical and laboratory monitoring of response and tolerance is recommended. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms or any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or irregular heartbeats. It may be necessary to reduce theophylline dosage.
- Lee BL, Dohrmann ML "Theophylline toxicity after propafenone treatment: evidence for drug interaction." Clin Pharmacol Ther 51 (1992): 353-5
- Spinler SA, Gammaitoni A, Charland SL, Hurwitz J "Propafenone-theophylline interaction." Pharmacotherapy 13 (1993): 68-71
Generic Name: guaifenesin / oxtriphylline
Brand name:
Synonyms: Oxtriphylline and guaifenesin (Oral)
Generic Name: propafenone
Brand name: Rythmol, Rythmol SR
Synonyms: Propafenone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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